Select scientific publications from Neurona employees, founders and collaborators:
Human MGE cell derivation methods and review of therapeutic potential
- Bershteyn, M, Broer, S., Parekh, M., Maury, Y., Havlicek, S, Kriks, S., Fuentealba, L., Lee, S., Zhou, R., Subramanyam, G., Sezan, M., Sevilla, E.S., Blankenberger, W., Spatazza, J., Zhou, L., Nethercott, H., Traver, D., Hampel, P., Kim, H., Watson, M., Salter, N., Nesterova, A., Au, W., Kriegstein, A., Alvarez-Buylla, A., Rubenstein, J., Banik, G., Bulfone, A., Priest, C. and Nicholas, C.R. Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy. Cell Stem Cell 30, 1–20, October 5, 2023. doi: 10.1016/j.stem.2023.08.013
- Southwell D. G., Nicholas C. R., Basbaum A. I., Stryker M. P., Kriegstein A. R., Rubenstein J. L., Alvarez-Buylla A. (2014). Interneurons from Embryonic Development to Cell-Based Therapy. Science, 344(6180), 1240622. doi:10.1126/science.1240622
- Nicholas C. R., Chen J., Tang Y., Southwell D. G., Chalmers N., Vogt D., Arnold C. M., Chen Y-J. J., Stanley E. G., Elefanty A. G., Sasai Y., Alvarez-Buylla A., Rubenstein J. L., Kriegstein A. R. (2013). Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell, 12(5), 573–586. doi:10.1016/j.stem.2013.04.005
MGE transplantation reduces seizures in rodent epilepsy models
- Hunt R. F., Girskis K. M., Rubenstein J. L., Alvarez–Buylla A., Baraban, S. C. (2013). GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nature Neuroscience, 16(6), 10.1038/nn.3392. doi:10.1038/nn.3392
- Baraban S. C., Southwell D. G., Estrada R. C., Jones D. L., Sebe J. Y., Alfaro-Cervello C, García-Verdugo, J. M., Rubenstein J. L. R., and Alvarez-Buylla A., Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. (2009) PNAS 106 (36) 15472-15477. doi:10.1073/pnas.0900141106
MGE transplantation improves learning and memory in rodent models of Alzheimer’s disease
- Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 Apr 4;98(1):75-89.e5. doi: 10.1016/j.neuron.2018.02.029. Epub 2018 Mar 15. PMID: 29551491; PMCID: PMC5886814.
- Tong L. M., Djukic B., Arnold C., Gillespie A. K., Yoon S. Y., Wang M. M., Zhang O., Knoferle J., Rubenstein J. L., Alvarez-Buylla A., Huang Y. (2014). Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with Aβ Accumulation. The Journal of Neuroscience, 34(29), 9506–9515. doi:10.1523/JNEUROSCI.0693-14.2014
MGE transplantation reduces neuropathic pain and spasticity in rodent models
- Fandel T. M., Trivedi A., Nicholas C. R., Zhang H., Chen J., Martinez A.F., Noble-Haeusslein L. J., Kriegstein A. R. (2016). Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury, Cell Stem Cell, doi: 10.1016/j.stem.2016.08.020. Epub 2016 Sept22
- Bráz J., Sharif-Naeini R., Vogt D., Kriegstein A., Alvarez-Buylla A., Rubenstein J., Basbaum A. (2012). Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron, 74(4), 663–675. doi:10.1016/j.neuron.2012.02.033
MGE transplantation ameliorates motor symptoms in rodent Parkinson’s model
- Martínez-Cerdeño V., Noctor S. C., Espinosa A., Ariza J., Parker P., Orasji S., Daadi M. M., Bankiewicz K., Alvarez-Buylla A., Kriegstein, A. R. (2010). Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats. Cell Stem Cell, 6(3), 238–250. doi:10.1016/j.stem.2010.01.004
MGE transplantation provides proof-of-concept inhibition and plasticity induction
- Southwell DG, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. (2010). Cortical plasticity induced by inhibitory neuron transplantation. Science, 327(5969):1145-8. doi: 10.1126/science.1183962
- Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban SC. (2006). Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci, 26(28):7380-9
Endogenous MGE interneuron migration and integration
